Protein–ligand structure elucidation using sparse NMR data

Organisation/Company: University of Vienna

Department: Department of Pharmaceutical Sciences

Research Field: Chemistry > Biochemistry, Physics > Biophysics

Researcher Profile: First Stage Researcher (R1)

Positions: Master Positions

Country: Austria

Application Deadline: 1 Dec:00 (Africa/Abidjan)

Type of Contract: Not Applicable

Job Status: Not Applicable

EU Funding: Not funded by a EU programme

Research Infrastructure Staff Position: No

Offer Description

• “Protein–ligand structure elucidation using sparse NMR data”

Julien Orts’ group “BioNMR and Drug Discovery by Advanced NMR Methods” at the University of Vienna is seeking a highly motivated student to join their team.

The project focuses on developing new approaches for protein–ligand structure determination. The team has recently proposed NMR2, a method for rapid elucidation of protein–ligand complex structures without requiring crystallography or protein resonance assignment.

Your role will be to further develop and explore this method. Candidates should have a strong interest in advanced biophysical and spectroscopic techniques applied to biological problems, with knowledge in physical chemistry or computational sciences. The position offers extensive training in structural biology and advanced NMR methods, a collaborative environment, and opportunities for cutting-edge research.

Applicants should submit a motivation letter and CV. Relevant publications include

• Torres F et al., J Med Chem. 2022 Apr 14;65(7):. “NMR Molecular Replacement Provides New Insights into Binding Modes to Bromodomains of BRD4 and TRIM24”
• Orts J, Riek R, J Biomol NMR. 2020 Nov;:. “Protein-ligand structure determination with the NMR molecular replacement tool, NMR2”

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